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These adverse effects were mainly represented by heart failure emphasizing the necessity of prolonged cardiac follow-up after ICI therapy (200)

LONZA LONZA is a global multinational company with a history of over 100 years and a leading position in biochemistry, fine chemistry, and functional chemistry with its headquarters in Basel, Switzerland

It recruited 502,713 people (intended to be aged 4069 years, mean age 56.5 years, 45.6% men) from 2006 to 2010 in England, Scotland, and Wales, 94% of self-reported European ancestry

J Cardiovasc Pharmacol 72(5):231241

Researchers first identified it decades ago and later discovered that levels tend to decline with age

[1] It is a ubiquitous compound with a biologically active sulfhydryl group contributed by the cysteine moiety that acts as the active part of the molecule