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Both classes are highly effective in reducing cardiovascular events in patients with type 2 diabetes across the spectrum of CVD risk (notably, our prior work comparing across mediation classes suggests that SGLT2is may be even more favorable than GLP-1RAs for some outcomes, and are comparable on others), and we assume that taking both together is likely to be even more beneficial

Current Access Landscape Neither Mazdutide nor Retatrutide has received Health Canada approval as of late 2025

No documented interaction exists in UK prescribing information or published clinical studies

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There is also Rybelsus , an oral semaglutide tablet approved for Type 2 diabetes, though not typically used for weight loss due to lower bioavailability

it is a tool that works best when paired with the right stimulus