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It differs from the native 70 residue growth factor by an arginine-for-glutamate substitution at position 3 and a hydrophobic 13 residue N-terminal extension, MFPAMPLLSLFVN, which is itself a residual fragment of the methionyl porcine growth hormone fusion partner used to express the protein in Escherichia coli
Hum Reprod Update, 16(3), 231-245
It binds to the GHS-R1a receptor, which triggers a GH pulse through a different signaling cascade
In a Feb
*These statements have not been evaluated by the US FDA
10.1007/s00125-012-2534-0 74
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