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George R
(Progesterone has the opposite effect in the urinary bladder, raising the threshold of response, but strengthening contraction, as it does in the gallbladder.) Estrogen lowers stimulation threshold in the gallbladder, as it does in the brain
It is something that researchers are still grappling with
Therefore, these could be considered a priori functional circuits of interest in studies of putative neuroinflammatory conditions such as ME/CFS
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