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This activation results in numerous changes in cells, including the production of TNF, IL-1, and IL-6, which are pro-inflammatory cytokines with various effects on the host

Research-context answer There is no approved missed-dose guidance

[1] Aspartyl residues in peptides are known to be susceptible to isomerization, and DSIP contains both an Asp residue and adjacent Gly the sequence context most associated with that rearrangement