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[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency

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[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

TFA Removed: Minimized trifluoroacetic acid content to prevent cytotoxicity in sensitive primary cell lines