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If glutathione (GSH) levels are low, these toxins are not efficiently removed from the body and can cause damage to cellular DNA, cell membranes, and mitochondria, which can result in an array of symptoms and disease, contribute to existing medical conditions (such as infertility), and cause problems with pregnancy and the future health of the offspring

doi: 10.1074/jbc.M803623200

Phase I uses cytochrome P450 enzymes to transform the toxins, and often what is produced here, called intermediates, are incredibly toxic to the body so an additional transformation is required

Mursaleen, L., Somavarapu, S