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Enteroendocrine cells express functional Toll-like receptors

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Available from: Bastin, M., & Andreelli, F

GLP-1-activated PKA inhibits voltage-gated potassium channels, prevents membrane repolarization, and prolongs VDC channel opening to promote Ca 2+ inward currents, contributing to GLP-1 stimulate insulin secretion, and the antagonistic effect of GLP-1R activation on Kv currents in cells requires transactivation of epidermal growth factor receptors, accompanied by signal conduction of cAMP/PKA and phosphatidylinositol-3-kinase (PI3K)/PKC signaling (MacDonald et al., 2003)

Both have natural origins

The overall mean maternal age was 28.7 3.3 years, infant gestational age was 39.4 0.6 weeks, and infant birth weight was 3.7 0.3 kg