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Open systems cost less to operate, they can be easily maintained, are directly exposed to sunlight, accumulate less dissolved oxygen

Peptides below roughly the glomerular filtration threshold are cleared renally, which is why kidney function is a meaningful covariate for small peptides

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[1] In these studies, treated animals showed no increase in cardiac fibrosis on histology, no chamber dilation by gross anatomy, and no elevation in cardiac troponin T compared to age-matched controls