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This dual affinity creates a unique pharmacological effect within the family: cardioprotection demonstrated in myocardial ischemia-reperfusion models with a 2540% reduction in infarct size, an effect preserved in GHS-R1a knockout animals but abolished in CD36 knockout animals (formal mechanistic evidence of the CD36-independent pathway)

doi: 10.1210/en.2012-1937 194 RakipovskiGRolinBNhrJKleweIFrederiksenKSAugustinRet al

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