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The Legal Arguments Plaintiffs Claim: Manufacturers (Novo Nordisk, Eli Lilly) knew or should have known about risks of gastroparesis and NAION Warning labels failed to adequately disclose these serious side effects Drugs were aggressively marketed as safe and effective weight loss solutions without proper risk disclosure Patients would not have taken the medications had they known the true risks Defendants Respond: Claims are unfounded (Novo Nordisk statement) Will defend vigorously against lawsuits Motion to dismiss expected January 24, 2025 Argue that labels were adequate and that many conditions may be pre-existing or related to diabetes itself Whos Most at Risk

Research tool Model MC1R Reference in pharmacology: melanocortin for melanocyte cells (B16, MNT-1) and cAMP/PKA/MITF/tyrosinase signaling studies

Philippou A, Maridaki M, Pneumaticos S, Koutsilieris M

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Mulder TP, Peters WH, Wobbes T, Witteman BJ and Jansen JB