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The challenge is to get these results into clinical practice, to get the drug used by the people who will benefit from it, who will live longer without dialysis, without heart attacks, without strokes, if they take this drug. Conducted between June 2019 and May 2021, the trial saw half of all patients receiving a 1 mg dose of semaglutide each week, and half receiving a placebo
The difference is almost entirely attributable to water and glycogen depletion rather than true fat loss
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Secondary outcomes showed semaglutide reduced myocardial infarction (HR 0.81) and stroke (HR 0.84) versus sitagliptin, while tirzepatide was non-inferior to dulaglutide for mortality, myocardial infarction, and stroke
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