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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, for the Treatment of Obesity in People With Type 2 Diabetes (ATTAIN-2): A Phase 3, Double-Blind, Randomised, Multicentre, Placebo-Controlled Trial
At that time, about 23,000 State Health Plan members were using the drugs, which were costing the plan more than $800 monthly after rebates
Minda Down 9Olbs
As different APOE genotypes are shown to have different energy substrate preferences it is not surprising that L-carnitine administration affected levels of these FAO metabolites differently by genotype (Yassine and Finch, 2020)
Baseline labs anchor the decision: bloodwork is ordered before any vial is opened, not after the patient is already cycling
Other limitations included potential residual confounding, reliance on electronic health record diagnostic codes, lack of medication adherence and patient-level weight-change data, grouping of different GLP-1RAs, and limited precision in later estimates because many patients were censored around 5 years
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