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They are downstream consequences of a chain of events that started with rapid weight loss and gallstones
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In type 2 diabetes, the cells become resistant to insulin
When one health system compared more than a thousand bariatric-surgery patients with about two thousand people on semaglutide or tirzepatide, surgery caused more total weight loss and more absolute muscle loss, but the share that came off as lean stayed in the same modest range for both (2026 cohort)
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Primary care physicians will likely need education and training focused on this new class of medications, given a shortage of endocrinologists and obesity medicine specialists. Lee and colleagues noted there were study limitations, such as a lack of data on prescription indication, including whether it was used off-label. However, the increase in dispensing of injectable semaglutide for weight management suggests increasing use for this indication, they wrote
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