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In the end, the goal is that Massachusetts patients like Alice and Brian can get the treatments they need without the healthcare system buckling under the cost

Data availability The authors declare that all data supporting the findings of this study are provided in the Manuscript and its Supplementary Information/Source Data files

These reactions frequently diminish or resolve as the biological system acclimates to the new compound

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NAPstars specifically respond to dynamic NADP redox changes in vitro To further test the dynamic and specific responsiveness of NAPstars to changes in NADP redox status, we used recombinant NAPstar probes to monitor NADP dynamics in enzyme assays in vitro (Supplementary Fig

4.2 Kinetic models Kinetic models that express how changes in metabolite concentrations affect local reaction rates are able to dynamically analyse the metabolic state of biological systems and also provide dynamic simulation of metabolism by implementing reaction kinetics (Smallbone & Mendes, 2013)