Even with human-grade cagrilintide, side effects can still occur
Potential Heart Attack Risk: Although uncommon, reports suggest the need for vigilance in patients with pre-existing heart conditions
A 2022 review of 76 clinical trials noted participants who used GLP-1s specifically for weight loss, took a higher dose, and/or used the medication for more than 26 weeks were at a higher risk for gallbladder issues
The rationale for oral administration is direct mucosal contact
Patients should be advised to eat smaller, more frequent meals, avoid high-fat or spicy foods, and remain well hydrated during the initial treatment period
many centres recommend pausing for 1-7 days before the procedure Pre-assessment screening : Anaesthetic teams routinely ask about GLP-1 agonist use during pre-operative assessment Patient communication : GPs and prescribing services should inform patients about the need to discuss treatment with their anaesthetic team before planned procedures Documentation : Clear recording in medical notes and communication with the surgical team Importantly, patients using GLP-1 receptor agonists for diabetes should not stop their medication without consulting their diabetes team, as alternative glucose-lowering strategies may be needed