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A: Existing studies report good safety profiles, but long-term data in humans is limited
This metabolic flexibility is essential for the maintenance of cardiac function
Most researchers regain 1 to 3 pounds in the first two weeks off (primarily water weight and increased GI contents), then 1 to 2 pounds per month thereafter as appetite normalizes and caloric intake creeps back up
Eur Heart J Cardiovasc Pharmacother 2018;4:180e8
It's important to note that tirzepatide does cause small increases in resting heart rate (2-4 beats per minute), which is documented in the FDA labeling
Okonogi N, Ebara T, Ishikawa H, Yoshida D, Ueno M, Maeno T, Suga T, Nakano T
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