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Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro

Stress Disulphidebond formation in the ER of both mammalian and yeast cells can lead to the formation of ROS (Harding et al , 2003

Bioconjugate Chem

Starting with lower doses and gradually increasing allows the body to adjust and reduces the likelihood of systemic reactions

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Xue et al., 2004a