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All three medications belong to the GLP-1 receptor agonist class but have some key differences: Mounjaro (Tirzepatide): Mechanism: Dual GIP and GLP-1 receptor agonist Administration: Once-weekly injection Average Weight Loss: Up to 22.5% of body weight in 72 weeks [1] Primary Indication: Type 2 diabetes (weight loss indication pending) Price at Great North Pharmacy: Starting at $158.99 per vial [2] Ozempic (Semaglutide): Mechanism: GLP-1 receptor agonist Administration: Once-weekly injection Average Weight Loss: Up to 15% of body weight in 68 weeks [6] Primary Indication: Type 2 diabetes (approved for weight loss under brand name Wegovy) Price at Great North Pharmacy: Starting at $429.97 for 1 pen [2] Saxenda (Liraglutide): Mechanism: GLP-1 receptor agonist Administration: Daily injection Average Weight Loss: Up to 8% of body weight in 56 weeks [7] Primary Indication: Chronic weight management Price at Great North Pharmacy: Starting at $515 for 5 pens [2] Effectiveness: Clinical trials suggest that Mounjaro may lead to greater weight loss compared to both Ozempic and Saxenda
However, because its primary FDA approval is for diabetes management rather than weight loss per se, getting insurance to cover it specifically for weight loss can present additional hurdles
Both peptides improve a constellation of metabolic markers, and the differences here may ultimately matter more than the weight loss gap for certain populations
