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Interestingly, superimposing the SH3arr1 complexes onto the crystal structure of autoinhibited Src phosphorylated at Y527 reveals steric clashes of arr1 with the SH2 and SH1 domains, suggesting that arr1 cannot access the SH3 domain in this conformation (Supplementary Fig
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Catalytic iron and acute kidney injury
Loss of CAV1 in fibrotic lungs enhances GLS1 expression, while treatment with the CAV1-derived peptide CSP7 alleviates fibrosis [102]
doi: 10.1038/s41390-019-0497-2 38
Clinical Evidence for Effects on Skin The topical peptide review by Schagen summarized placebo-controlled and comparative studies in which Cu-GHK products were associated with collagen production and visible skin-aging measures [2]
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