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This also becomes highly relevant in animals living at extremely high latitudes where persistent darkness for long periods totally eliminates the blood melatonin rhythm, sometimes for multiple months of the year (55)

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Experimental studies investigating BSCB disruption in rat spinal cords following irradiation have demonstrated that serum albumin leakage occurs 24 h post-irradiation, which correlated with heightened ICAM-1 expression on both endothelial and glial cells

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