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The phentermine label specifically warns against using it with other weight loss medications
Taken together, all these issues make less weight loss an expected finding in SELECT, compared with STEP 1
The mechanism is fascinating: Unlike GLP-1 agonists that work on gut hormones, tesofensine directly modulates brain neurotransmitters controlling appetite and energy expenditure
In the REDEFINE 2 trial in patients with type 2 diabetes, it achieved 13.7% weight loss and brought 73.5% of patients to HbAc 6.5% ( [141] )
Diabetes 16, 12501262
Annu Rev Immunol 32:609634
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