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Regulatory note: The FDA added injectable GHK-Cu to a high-risk compounded substance list in September 2023

It comes down to absorption

68,69 In a rat model of overactive bladder, an herbal extract combination of these ingredients improved bladder function and levels of biomarkers associated with bladder overactivity

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Sikiri has said the risk is "entirely excluded," based on a cell study from 2004 a statement widely criticised, because the human safety data simply are not there