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A physician's unfamiliarity with peptides isn't a sign that the compounds are invalid

The extracellular HMGB1 acts as a DAMP molecule which produces several redox forms that bind with multiple receptor types thereby inducing a cascade of inflammatory responses, particularly in diabetes

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Taking both together makes sense for most people, though folate status should be adequate before starting high-dose b12 to avoid masking folate deficiency

Some individuals may not respond to NAC, and benefits, if any, are likely to be modest compared to established interventions

Petersen KM, et al