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Starting with fewer compounds and adding based on response is a prudent approach

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(PubMed) Xue YZ, Wang LX, Liu HZ, Qi XW, Wang XH, Ren HZ

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The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice

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28,29 Similarly, methylation or mutation of rRNA can confer resistance to macrolides, lincosamides, or tetracyclines

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Disclose it to your prescriber as you would any supplement

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