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clinical complexity slows uptake Long-acting or micro-dosages (e.g., monthly injections, microneedle patches) What changes: Improved tolerability, better adherence Where it moves : Possibly back toward DTC models if access outpaces infra Strategic shift: Less patient burden, potential wedge for intermediaries Risk: Manufacturing lag or cost may stall rollout
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Am J Physiol Endocrinol Metab 2010;298:E751-E760
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