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Common side effects include: Nausea Vomiting Diarrhea Constipation Abdominal pain These are typically mild and lessen over time

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Smokers are 2-7 times more likely to develop severe cases, while diabetics face triple the risk due to impaired healing and increased inflammation

Supplementary Data 3 (download XLSX Summary of identified adverse events in adult patients

"This is where we see a lot of errors

1 Major epigenetic mechanisms include DNA methylation, histone modifications (e.g., methylation, acetylation, lactylation), chromatin remodeling, and noncoding RNA-mediated regulation