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Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction

Edmonson, et al

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Due to its effects on weight loss, semaglutide was also approved in 2021 for weight management under the name Wegovy

Compound-Specific Oncologic Effects As highlighted in this meta-analysis, no conclusive association between the use of GLP-1 RAs and an increase in gastrointestinal cancers has been established