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Gozes group has found that ADNP mutations affect MT dynamics and inhibit its interactions with Tau [348, 349], producing a tauopathy-like phenotype manifested in increased GSK-3 activity, Tau hyper-phosphorylation, and cognitive deficiency [293]
It is more often discussed as a repair-focused compound because of its proposed effects on inflammation, tissue healing, angiogenesis, and mucosal protection
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Angew Chem Int Ed 49(39):70497053
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multi-compound pathway research, formulation comparison, synergistic research models
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