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T2DM itself is known to disrupt the gut microbiome, often leading to reduced diversity and a decline in beneficial genera like Bifidobacterium, Bacteroides, and Faecalibacterium, with increases in potentially harmful genera such as Ruminococcus, Fusobacterium, and Blautia

FOXO3 also prevents pro-apoptotic BAX translocation to the mitochondria, hence protecting cells from apoptosis 100

Collectively, these effects create a microenvironment conducive to cellular recovery and tissue repair in experimental models

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The survival rates depend on type, detection, and treatment plans

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