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The problem is that the bodies of other animals also makes all that they need, so when we eat them, their carnitine can end up in our gut for those bacteria to feast uponresulting in TMAO
Blood loss, especially from dialysis, infection, inflammation, and malnutrition, is another contributing factor
The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake
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