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In both, these effects are dose-dependent and tend to ease as the dose is escalated gradually
All of these effects compound the digestive slowing already caused by your medication, creating a worse environment for fermentation and gas production
A glass of water immediately increases gastric pH in healthy subjects
G.VerhoefJ
Increased glycosaminoglycan synthesis : Reviewed in Pickart & Margolina 2018, supporting structural hydration capacity
Your heart has to work harder when blood volume drops due to lack of fluids
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