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Clinical trials showed average weight loss of 20-25% of body weight with tirzepatide at the highest doses, compared to 15-17% with semaglutide

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Zepbound is not the diabetes-branded tirzepatide product Current FDA labeling indicates Zepbound for long-term weight reduction in adults with obesity or adults with overweight plus at least one weight-related condition, and for moderate-to-severe obstructive sleep apnea in adults with obesity

Decreasing the burden of non-alcoholic fatty liver disease: From therapeutic targets to drug discovery opportunities

No evidence of hormonal, hepatic, or cardiovascular adverse effects has been observed in available data

Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from dual agonists like tirzepatide and single agonists like semaglutide