Recent studies have found that trihydroxychalcone is a treatment for AD by simultaneously inhibiting A 1 42 aggregation and ferroptosis (Cong et al., 2019), and ferroptosis-specific inhibitor Fer-1 can inhibit the accumulation of ROS/RNS and reduce the accumulation of -synuclein under rotenone-induced oxidative stress, then protect neuroblastoma cells SH-SY5Y (Kabiraj et al., 2015)
HGF protein benefits are largely dependent on the way of administration, mostly due to HGF short half-life and poor accessibility to the BBB
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Wickman A, Isgaard J, Adams MA, Friberg P: Inhibition of nitric oxide in rats