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Recent single-cell transcriptomic studies reveal these virulence factors synergistically induce epithelial-mesenchymal transition (EMT) signatures and cancer stem cell marker expression in preneoplastic lesions (Zhu et al., 2017).By catalyzing the hydrolysis of glutamine and glutathione, -glutamyl-transpeptidase (GGT) facilitates the generation of ROS and ammonia
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By selectively binding to the ghrelin receptor in experimental systems, researchers can evaluate hormone release dynamics, receptor activation patterns, and intracellular signaling responses
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