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Many patients report that their GLP-1 medication becomes less effective after several months of usea phenomenon called tolerance or adaptation

10.1038/nbt.2676 116

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If you stop taking them, hunger and cravings may return, increasing the risk of weight regain

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The major downside is that nearly all oral BP products must be taken on an empty stomach and swallowed with a full glass of water, with at least a half hour intervening before anything other than water is ingested