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Previous medication trials: Most plans require youve tried and failed (or have contraindications to) first-line diabetes medications like metformin

Hydration needs: daily fluid intake should reach 8 to 12 cups as these medications reduce thirst signals

The phase 2 dose-response was orderly, which is reassuring from a pharmacology standpoint because a clean dose-dependence argues that the effect is real and mechanism-driven rather than an artifact

A 2017 study by Tejera-Segura and colleagues showed RA patients often have hidden insulin resistance driven by chronic inflammation

Skipping the warm-up is the injury risk most people underestimate