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MT-2 incorporates a D-phenylalanine substitution at position 7 and a lactam bridge between positions 4 and 10, modifications that enhance receptor binding affinity and metabolic stability relative to native alpha-MSH

If symptoms remain severe beyond 3-4 weeks at a stable dose, medical consultation is warranted to assess whether continuation at that dose level is appropriate

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5 Mounjaro can also reduce the effectiveness of oral contraceptives during the first weeks of treatment and after each dose increase, due to delayed gastric emptying

Members of the public are urged to report suspicious medicine sales or false claims of SAHPRA approval through the Authoritys 24-hour hotline (0800 204 307) or its online reporting platform

The standard dosing schedule starts with 0.25 mg weekly for the first four weeks, increases to 0.5 mg weekly from weeks five through eight, and then may escalate to 1 mg or 2 mg weekly depending on tolerance and response