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Its emergence reshaped the field's expectations for incretin-based compounds and laid the conceptual foundation for the subsequent triple-agonist class exemplified by retatrutide

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Sitagliptin Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones

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This improves immune modulation and reduces inflammation and autoimmunity