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10.1038/npp.2014.175 50 HsuT

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Understanding Melanotan II and How It Works Melanotan II is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (MSH), designed to bind and activate melanocortin receptors

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However, this caused many side effects

at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects