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Lifestyle Factors Studies indicate that your diet and medication use can affect how long vitamin B12 stays in the body

For example, sugar alcohols like sorbitol or mannitol (used in some chewable or effervescent preparations) can have osmotic effects, drawing water into the intestinal lumen and potentially leading to loose stools in sensitive individuals

However, protocols extending beyond 6 months in humans rely on extrapolation rather than controlled studies

NICE guidance recommends intramuscular hydroxocobalamin as first-line treatment for B12 deficiency caused by pernicious anaemia or malabsorption

Some clinics offer memberships or sliding scales

Semaglutides maximum approved dose for weight management is 2.4mg weekly