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In STEP-1 (N=1,961), semaglutide 2.4 mg produced 14.9% mean body weight loss at 68 weeks versus 2.4% with placebo, and the lipid improvements tracked closely with this weight reduction 1

Topiramate, originally approved for seizure management and migraine prevention, reduces appetite by modulating GABA receptors and carbonic anhydrase activity

Reduce consumption of foods that trigger symptoms: For some, ultra-processed and spicy foods tend to make symptoms worse [13]

Its not a replacement for the drug, but it does serve as a complementary signal

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There has been research about enhancing hydrogen production by CB through genetic and metabolic methods