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The majority is stored in skeletal muscle (~60%) and bone (~30%), with additional pools found in the liver (~5%), skin (~5%), pancreas, kidney and brain 22
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This structural modification significantly extends its half-life and enhances resistance to proteolytic degradation, thereby enabling prolonged biological activity in vivo
The Phase 2 trial protocol permitted injection at any time of day, provided the once-weekly interval was maintained consistently
aeruginosa colonization, is associated with lower systemic CAT in CF children ( 7.4.3 GPx Studies highlight GPxs substantial role, with abundant reduced thiols, in detoxifying H 2 O 2 in CF sputum, particularly when CAT is inhibited or overwhelmed (Ward et al., 1984)