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These microbial-derived signals activate hepatic immune pathways, including toll-like receptor-mediated responses, thereby promoting inflammation, hepatocellular injury, and fibrogenesis
After the start of GLP-1RA treatment, participants were deemed to have discontinued the drug if they did not receive a refill for 90 days after their prescription ended
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10.3389/fphar.2021.611480 9
This conformational change further transduces through F279 6.51 and H280 6.52 to cause rearrangement of an aromatic cluster formed by residues W276 6.48 , F279 6.51 , H280 6.52 , and F312 7.42 (Fig
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