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Efeyan, A
This compound is not for human consumption
in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation
Utilizing a variety of animal models of TMJ OA caused by unilateral anterior crossbite (UAC), occlusion disorder (OD), monosodium iodoacetate (MIA), and IL-1, the study shows that ferroptosis, which is typified by elevated p53 and ACSL4 and decreased GPX4, is a major contributor to TMJ OA
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