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doi:10.1002/mnfr.201000648

A glycosylated FGF21 variant, LY2405319, maintains the molecular size of endogenous FGF21 but improves its thermal stability and reduces aggregation by engineering an additional disulfide bond and a small number of point mutations into the molecule (291)

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Given the tremendous costs of treating cardiovascular disease and continuing renal replacement therapy, the suspected total benefits obtained from therapy should not be overlooked