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Hold the vial up to a light source, a window or a lamp
During Phase 1 detoxification, a family of enzymes known as Cytochrome P450 (CYP450) modifies toxins through oxidation
When the delicate lining of the gut becomes damaged, it sets off a cascade of systemic inflammation that can perpetuate the cycle of chronic illness
Tirzepatide SURMOUNT-1 (2022) and SURPASS-2 (2021) SURMOUNT-1 (Jastreboff et al., NEJM 2022): 2,539 non-diabetic adults with BMI 30, 72 weeks of tirzepatide 15 mg/week: Weight loss: 20.9% (vs 3.1% placebo) 91% of participants 5% loss, 56.7% 20% SURPASS-2 (Fras et al., NEJM 2021): 1,879 T2D patients head-to-head vs semaglutide 1 mg: HbA1c: 2.30% (tirzepatide 15 mg) vs 1.86% (semaglutide) Weight loss: 11.2 kg vs 5.7 kg Tirzepatide statistically outperforms semaglutide on both HbA1c and weight in a head-to-head trial a rare outcome in incretin pharmacology
Pushing past these plateaus means taking steps to break that equilibrium
The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice
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