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Nakamura T, Iwanaga Y, Miyaji Y, Nohara R, Ishimura T, Miyazaki S, et al

CD8 + T lymphocytes can upregulate perforin expression and increase MMP activity, resulting in the airway and lung tissue destruction, as well as chemotactic activation of inflammatory cells through secretion of cytokines such as interferon, IL-12, TNF- and chemokines, exacerbating the inflammatory response