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Many prescribers use a dose escalation strategy , starting patients on a lower dose and gradually increasing it over several weeks

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Lancet 2005

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The orally administered semaglutide phase 3a programme evaluated the efficacy, safety and tolerability of once-daily orally administered semaglutide in 9543 randomised subjects with T2D, of whom 5707 were exposed to orally administered semaglutide