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Studies have described that flavonols and their derivatives are likely the substrate for GSTLs, which tightly bind to these small molecules ( Arabidopsis and wheat Lambda class GSTs ( AtGSTL1, TaGSTL1 , and TaGSTL3) have been identified to be localized in cytosol, whereas others ( AtGSTL2 and TaGSTL2) are chloroplast localized (Theodoulou et al., 2003)

In addition, Danish pharmaceutical company Novo Nordisk announced it will lower the list price of several of its GLP-1 drugs namely Wegovy, Rybelsus and Ozempic by 35% to 50% from the current list price

Pre-clinical data from studies that combine GLP-1R agonism with other weight loss strategies such as AGB or other metabolic hormones have highlighted more potent options for weight loss

Otherwise, current recommendations are for patients to be screened for baseline diabetic retinopathy before initiating GLP-1RA and participate in personalized risk discussions